The missing link between clinical states and biomarkers in mental disorders

Fava, Giovanni A.; Guidi, Jenny; Grandi, Silvana; Hasler, Gregor (2014). The missing link between clinical states and biomarkers in mental disorders. Psychotherapy and psychosomatics, 83(3), pp. 136-141. Karger 10.1159/000360348

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Current diagnostic definitions of psychiatric disorders based on collections of symptoms encompass very heterogeneous populations and are thus likely to yield spurious results when exploring biological correlates of mental disturbances. It has been suggested that large studies of biomarkers across diagnostic entities may yield improved clinical information. Such a view is based on the concept of assessment as a collection of symptoms devoid of any clinical judgment and interpretation. Yet, important advances have been made in recent years in clinimetrics, the science of clinical judgment. The current clinical taxonomy in psychiatry, which emphasizes reliability at the cost of clinical validity, does not include effects of comorbid conditions, timing of phenomena, rate of progression of an illness, responses to previous treatments, and other clinical distinctions that demarcate major prognostic and therapeutic differences among patients who otherwise seem to be deceptively similar since they share the same psychiatric diagnosis. Clinimetrics may provide the missing link between clinical states and biomarkers in psychiatry, building pathophysiological bridges from clinical manifestations to their neurobiological counterparts.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Healthcare Research

UniBE Contributor:

Hasler, Gregor

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0033-3190

Publisher:

Karger

Language:

English

Submitter:

Gregor Hasler

Date Deposited:

22 Aug 2014 07:47

Last Modified:

30 Dec 2016 11:33

Publisher DOI:

10.1159/000360348

PubMed ID:

24732705

Uncontrolled Keywords:

Biomarkers, Biological psychiatry, Clinical judgment, Clinimetrics, Staging, Psychiatric diagnosis, Mental disorders, Depressive disordes, Antidepressant agents, Tolerance

BORIS DOI:

10.7892/boris.53477

URI:

https://boris.unibe.ch/id/eprint/53477

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