Metabotropic glutamate receptor 5 binding in patients with obsessive-compulsive disorder

Akkus, Funda; Terbeck, Sylvia; Ametamey, Simon M; Rufer, Michael; Treyer, Valerie; Burger, Cyrill; Johayem, Anass; Mancilla, Baltazar Gomez; Sovago, Judit; Buck, Alfred; Hasler, Gregor (2014). Metabotropic glutamate receptor 5 binding in patients with obsessive-compulsive disorder. International journal of neuropsychopharmacology, 17(12), pp. 1915-1922. Cambridge University Press 10.1017/S1461145714000716

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Obsessive-compulsive disorder (OCD) is a disabling, mostly chronic, psychiatric condition with significant social and economic impairments and is a major public health issue. However, numerous patients are resistant to currently available pharmacological and psychological interventions. Given that recent animal studies and magnetic resonance spectroscopy research points to glutamate dysfunction in OCD, we investigated the metabotropic glutamate receptor 5 (mGluR5) in patients with OCD and healthy controls. We determined mGluR5 distribution volume ratio (DVR) in the brain of ten patients with OCD and ten healthy controls by using [11C]ABP688 positron-emission tomography. As a clinical measure of OCD severity, the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was employed. We found no significant global difference in mGluR5 DVR between patients with OCD and healthy controls. We did, however, observe significant positive correlations between the Y-BOCS obsession sub-score and mGluR5 DVR in the cortico-striatal-thalamo-cortical brain circuit, including regions of the amygdala, anterior cingulate cortex, and medial orbitofrontal cortex (Spearman's ρ's⩾ = 0.68, p < 0.05). These results suggest that obsessions in particular might have an underlying glutamatergic pathology related to mGluR5. The research indicates that the development of metabotropic glutamate agents would be useful as a new treatment for OCD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Healthcare Research
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > UPD Murtenstrasse

UniBE Contributor:

Akkus, Funda; Terbeck, Sylvia and Hasler, Gregor

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1461-1457

Publisher:

Cambridge University Press

Language:

English

Submitter:

Gregor Hasler

Date Deposited:

11 Jun 2014 09:41

Last Modified:

15 May 2015 02:30

Publisher DOI:

10.1017/S1461145714000716

PubMed ID:

24833114

Uncontrolled Keywords:

anxiety, glutamate, neuroimaging, obsession

BORIS DOI:

10.7892/boris.53487

URI:

https://boris.unibe.ch/id/eprint/53487

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