Functional and anatomical outcome of eyes with neovascular age-related macular degeneration treated with intravitreal ranibizumab following an exit strategy regimen.

Menke, Marcel N; Zinkernagel, Martin S; Ebneter, Andreas; Wolf, Sebastian (2014). Functional and anatomical outcome of eyes with neovascular age-related macular degeneration treated with intravitreal ranibizumab following an exit strategy regimen. British journal of ophthalmology, 98(9), pp. 1197-1200. BMJ Publishing Group 10.1136/bjophthalmol-2013-304775

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AIMS To assess the functional and morphological outcome of eyes with neovascular AMD treated with intravitreal ranbizumab following an exit strategy treatment regime. METHODS The Bern treatment regime for neovascular AMD has a fixed injection schedule, even in the non-active stage of the disease. The regimen has been adapted from the PIER study treatment protocol. Eyes with non-active AMD will receive 4 injections in the first year, and 2 injections in the second year of follow-up before treatment stops. Patients that received ranibizumab for treatment and reached the exit criteria were identified, and charts were reviewed to assess functional and morphological outcome. RESULTS Only 2.6% of all patients (15 out of 575 patients) reached the exit criteria. Mean change in best corrected ETDRS visual acuity (VA) was 4.5±16.9 letters when comparing baseline VA to 4 weeks after the last injection (p=0.32). OCT mean foveal thickness was significantly thinner after last treatment (247.9±43.0 µm) compared to baseline (332.5±83.1 µm, p=0.002). The mean total number of ranibizumab injections was 15.6±8.0, and the mean total treatment period was 40.9±18.3 months. Twenty percent of eyes had geographic atrophy present at baseline versus 46.6% at the end of treatment. CONCLUSIONS Even with a fixed treatment regime and a defined treatment exit strategy, only a small percentage of patients reach exit criteria. Retinal thickness has been significantly reduced by repeated intravitreal ranibizumab injections, and geographic atrophy became more frequent.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Menke, Marcel; Zinkernagel, Martin; Ebneter, Andreas and Wolf, Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0007-1161

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

Sebastian Wolf

Date Deposited:

10 Oct 2014 15:34

Last Modified:

28 Jun 2016 11:18

Publisher DOI:

10.1136/bjophthalmol-2013-304775

PubMed ID:

24782472

Uncontrolled Keywords:

Macula, Neovascularisation, Pharmacology, Retina, Treatment, Medical

BORIS DOI:

10.7892/boris.53508

URI:

https://boris.unibe.ch/id/eprint/53508

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