Grey matter volumetric changes related to recovery from hand paresis after cortical sensorimotor stroke

Abela, Eugenio; Seiler, Andrea; Missimer, J.H.; Federspiel, Andrea; Hess, Christian W.; Sturzenegger, Matthias; Weder, Bruno J.; Wiest, Roland (2015). Grey matter volumetric changes related to recovery from hand paresis after cortical sensorimotor stroke. Brain structure & function, 220(5), pp. 2533-2550. Springer 10.1007/s00429-014-0804-y

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Preclinical studies using animal models have shown that grey matter plasticity in both perilesional and distant neural networks contributes to behavioural recovery of sensorimotor functions after ischaemic cortical stroke. Whether such morphological changes can be detected after human cortical stroke is not yet known, but this would be essential to better understand post-stroke brain architecture and its impact on recovery. Using serial behavioural and high-resolution magnetic resonance imaging (MRI) measurements, we tracked recovery of dexterous hand function in 28 patients with ischaemic stroke involving the primary sensorimotor cortices. We were able to classify three recovery subgroups (fast, slow, and poor) using response feature analysis of individual recovery curves. To detect areas with significant longitudinal grey matter volume (GMV) change, we performed tensor-based morphometry of MRI data acquired in the subacute phase, i.e. after the stage compromised by acute oedema and inflammation. We found significant GMV expansion in the perilesional premotor cortex, ipsilesional mediodorsal thalamus, and caudate nucleus, and GMV contraction in the contralesional cerebellum. According to an interaction model, patients with fast recovery had more perilesional than subcortical expansion, whereas the contrary was true for patients with impaired recovery. Also, there were significant voxel-wise correlations between motor performance and ipsilesional GMV contraction in the posterior parietal lobes and expansion in dorsolateral prefrontal cortex. In sum, perilesional GMV expansion is associated with successful recovery after cortical stroke, possibly reflecting the restructuring of local cortical networks. Distant changes within the prefrontal-striato-thalamic network are related to impaired recovery, probably indicating higher demands on cognitive control of motor behaviour.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Abela, Eugenio; Federspiel, Andrea; Hess, Christian Walter; Sturzenegger, Matthias; Weder, Bruno J. and Wiest, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1863-2653

Publisher:

Springer

Language:

English

Submitter:

Andrea Federspiel

Date Deposited:

02 Jul 2014 09:05

Last Modified:

01 Dec 2017 11:43

Publisher DOI:

10.1007/s00429-014-0804-y

PubMed ID:

24906703

Uncontrolled Keywords:

Cortical stroke, grey matter plasticity, tensor-based morphometry, motor recovery

BORIS DOI:

10.7892/boris.53579

URI:

https://boris.unibe.ch/id/eprint/53579

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