The Frontal Eye Field Is Involved in Visual Vector Inversion in Humans – A Theta Burst Stimulation Study

Frutiger, Kathrin; Cazzoli, Dario; Müri, René Martin; Bassetti, Claudio; Nyffeler, Thomas; Barton, Jason Jeremy Sinclair (2013). The Frontal Eye Field Is Involved in Visual Vector Inversion in Humans – A Theta Burst Stimulation Study. PLoS ONE, 8(12), e83297. Public Library of Science 10.1371/journal.pone.0083297

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In the antisaccade task, subjects are requested to suppress a reflexive saccade towards a visual target and to perform a saccade towards the opposite side. In addition, in order to reproduce an accurate saccadic amplitude, the visual saccade vector (i.e., the distance between a central fixation point and the peripheral target) must be exactly inverted from one visual hemifield to the other. Results from recent studies using a correlational approach (i.e., fMRI, MEG) suggest that not only the posterior parietal cortex (PPC) but also the frontal eye field (FEF) might play an important role in such a visual vector inversion process. In order to assess whether the FEF contributes to visual vector inversion, we applied an interference approach with continuous theta burst stimulation (cTBS) during a memory-guided antisaccade task. In 10 healthy subjects, one train of cTBS was applied over the right FEF prior to a memory-guided antisaccade task. In comparison to the performance without stimulation or with sham stimulation, cTBS over the right FEF induced a hypometric gain for rightward but not leftward antisaccades. These results obtained with an interference approach confirm that the FEF is also involved in the process of visual vector inversion.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Frutiger, Kathrin; Cazzoli, Dario; Müri, René Martin; Bassetti, Claudio and Nyffeler, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Valentina Rossetti

Date Deposited:

16 Jun 2014 13:55

Last Modified:

11 Dec 2014 02:05

Publisher DOI:

10.1371/journal.pone.0083297

BORIS DOI:

10.7892/boris.53731

URI:

https://boris.unibe.ch/id/eprint/53731

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