Synchronization and desynchronization in epilepsy: controversies and hypotheses

Jiruska, Premysl; de Curtis, Marco; Jefferys, John G. R.; Schevon, Catherine A.; Schiff, Steven J.; Schindler, Kaspar (2013). Synchronization and desynchronization in epilepsy: controversies and hypotheses. Journal of physiology, 591(4), pp. 787-797. Wiley-Blackwell 10.1113/jphysiol.2012.239590

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Epilepsy has been historically seen as a functional brain disorder associated with excessive synchronization of large neuronal populations leading to a hypersynchronous state. Recent evidence showed that epileptiform phenomena, particularly seizures, result from complex interactions between neuronal networks characterized by heterogeneity of neuronal firing and dynamical evolution of synchronization. Desynchronization is often observed preceding seizures or during their early stages; in contrast, high levels of synchronization observed towards the end of seizures may facilitate termination. In this review we discuss cellular and network mechanisms responsible for such complex changes in synchronization. Recent work has identified cell-type-specific inhibitory and excitatory interactions, the dichotomy between neuronal firing and the non-local measurement of local field potentials distant to that firing, and the reflection of the neuronal dark matter problem in non-firing neurons active in seizures. These recent advances have challenged long-established views and are leading to a more rigorous and realistic understanding of the pathophysiology of epilepsy.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Schindler, Kaspar Anton

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0022-3751

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Valentina Rossetti

Date Deposited:

17 Jun 2014 11:28

Last Modified:

13 Jan 2016 16:23

Publisher DOI:

10.1113/jphysiol.2012.239590

PubMed ID:

23184516

BORIS DOI:

10.7892/boris.53788

URI:

https://boris.unibe.ch/id/eprint/53788

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