Eosinophils

Radonjic-Hösli, Susanne; Simon, Hans-Uwe (2014). Eosinophils. Chemical immunology and allergy, 100, pp. 193-204. Karger 10.1159/000358735

[img] Text
358735.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

In 1846, T. Wharton-Jones described a coarsely granular stage in the development of granulocytic cells in animal and human blood. Shortly thereafter, Max Schultze redefined the coarsely granular cells as a type distinct from finely granular cells, rather than just a developmental stage. It was, however, not until 1879, when Paul Ehrlich introduced a method to distinguish granular cells by the staining properties of their granules, that a classification became possible. An intensive staining for eosin, among other aniline dyes, was eponymous for the coarsely granular cell type, which thereupon became referred to as eosinophil granulocyte. Eosinophilia had already been described in many diseases by the late 19th century. The role of these cells, however, today remains a matter of continuing speculation and investigation. Many functions have been attributed to the eosinophil over the years, often linked to increasing knowledge about the granular and cytoplasmatic contents. A better understanding of the regulatory mechanisms of eosinopoiesis has led to the development of knock-out mice strains as well as therapeutic strategies for reducing the eosinophil load in patients. The effect of these therapeutics and the characterization of the knock-out phenotypes have led to a great increase in the knowledge of the role of the eosinophil in disease. Today we think of the eosinophil as a multifunctional cell involved in host defense, tissue damage and remodeling, as well as immunomodulation.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Radonjic, Susanne Irene and Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1660-2242

Publisher:

Karger

Language:

English

Submitter:

Aniko Krebs

Date Deposited:

18 Aug 2014 11:23

Last Modified:

26 Apr 2017 02:28

Publisher DOI:

10.1159/000358735

PubMed ID:

24925399

BORIS DOI:

10.7892/boris.53817

URI:

https://boris.unibe.ch/id/eprint/53817

Actions (login required)

Edit item Edit item
Provide Feedback