Suicidal ideation in a European Huntington's disease population.

Hubers, Anna A. M.; van Duijn, Erik; Roos, Raymund A. C.; Craufurd, David; Rickards, Hugh; Landwehrmeyer, Bernhard G.; van der Mast, Rose C.; Giltay, Erik J.; The REGISTRYinvestigators, of the European Huntington's Disease Network; Schüpbach, Michael (2013). Suicidal ideation in a European Huntington's disease population. Journal of Affective Disorders, 151(1), pp. 248-258. Elsevier 10.1016/j.jad.2013.06.001

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BACKGROUND Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD. METHODS The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis. RESULTS At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood (OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive. LIMITATIONS As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated. CONCLUSIONS Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Schüpbach, Michael


600 Technology > 610 Medicine & health








Valentina Rossetti

Date Deposited:

18 Jun 2014 14:19

Last Modified:

29 Oct 2015 12:06

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Cohort studies Huntington's disease Psychopathology Psychopharmacology Suicidal ideation




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