Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume

Conductier, Grégory; Brau, Frédéric; Viola, Angèle; Langlet, Fanny; Ramkumar, Navean; Dehouck, Bénédicte; Lemaire, Thibault; Chapot, Raphaël; Lucas, Laurianne; Rovère, Carole; Maitre, Priscilla; Hosseiny, Salma; Petit-Paitel, Agnès; Adamantidis, Antoine Roger; Lakaye, Bernard; Risold, Pierre-Yves; Prévot, Vincent; Meste, Olivier; Nahon, Jean-Louis and Guyon, Alice (2013). Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume. Nature neuroscience, 16(7), pp. 845-847. Nature America 10.1038/nn.3401

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Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1097-6256

Publisher:

Nature America

Language:

English

Submitter:

Valentina Rossetti

Date Deposited:

18 Jun 2014 16:00

Last Modified:

29 Oct 2015 12:07

Publisher DOI:

10.1038/nn.3401

PubMed ID:

23708141

BORIS DOI:

10.7892/boris.53878

URI:

https://boris.unibe.ch/id/eprint/53878

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