Functional wiring of hypocretin and LC-NE neurons: implications for arousal.

Carter, Matthew E.; de Lecea, Luis; Adamantidis, Antoine Roger (2013). Functional wiring of hypocretin and LC-NE neurons: implications for arousal. Frontiers in behavioral neuroscience, 7(43), p. 43. Frontiers Research Foundation 10.3389/fnbeh.2013.00043

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To survive in a rapidly changing environment, animals must sense their external world and internal physiological state and properly regulate levels of arousal. Levels of arousal that are abnormally high may result in inefficient use of internal energy stores and unfocused attention to salient environmental stimuli. Alternatively, levels of arousal that are abnormally low may result in the inability to properly seek food, water, sexual partners, and other factors necessary for life. In the brain, neurons that express hypocretin neuropeptides may be uniquely posed to sense the external and internal state of the animal and tune arousal state according to behavioral needs. In recent years, we have applied temporally precise optogenetic techniques to study the role of these neurons and their downstream connections in regulating arousal. In particular, we have found that noradrenergic neurons in the brainstem locus coeruleus (LC) are particularly important for mediating the effects of hypocretin neurons on arousal. Here, we discuss our recent results and consider the implications of the anatomical connectivity of these neurons in regulating the arousal state of an organism across various states of sleep and wakefulness.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1662-5153

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Valentina Rossetti

Date Deposited:

18 Jun 2014 15:40

Last Modified:

26 Jun 2016 01:53

Publisher DOI:

10.3389/fnbeh.2013.00043

PubMed ID:

23730276

Uncontrolled Keywords:

arousal system, hypocretin, hypothalamus, neural circuits, norepinephrine, optogenetics, orexin, sleep

BORIS DOI:

10.7892/boris.53884

URI:

https://boris.unibe.ch/id/eprint/53884

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