Contactless conductivity detector array for capillary electrophoresis.

Stojkovic, Marko; Koenka, Israel Joel; Thormann, Wolfgang; Hauser, Peter C (2014). Contactless conductivity detector array for capillary electrophoresis. Electrophoresis, 35(4), pp. 482-486. Wiley-VCH 10.1002/elps.201300457

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A CE system featuring an array of 16 contactless conductivity detectors was constructed. The detectors were arranged along 70 cm length of a capillary with 100 cm total length and allow the monitoring of separation processes. As the detectors cannot be accommodated on a conventional commercial instrument, a purpose built set-up employing a sequential injection manifold had to be employed for automation of the fluid handling. Conductivity measurements can be considered universal for electrophoresis and thus any changes in ionic composition can be monitored. The progress of the separation of Na(+) and K(+) is demonstrated. The potential of the system to the study of processes in CZE is shown in two examples. The first demonstrates the differences in the developments of peaks originating from a sample plug with a purely aqueous background to that of a plug containing the analyte ions in the buffer. The second example visualizes the opposite migration of cations and anions from a sample plug that had been placed in the middle of the capillary.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Laboratory for Clinical Pharmacology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Thormann, Wolfgang

ISSN:

0173-0835

Publisher:

Wiley-VCH

Language:

English

Submitter:

Wolfgang Thormann

Date Deposited:

10 Oct 2014 22:09

Last Modified:

09 Dec 2014 09:04

Publisher DOI:

10.1002/elps.201300457

PubMed ID:

24285496

Uncontrolled Keywords:

CE, Contactless conductivity detection, Sequential injection analysis

BORIS DOI:

10.7892/boris.53970

URI:

https://boris.unibe.ch/id/eprint/53970

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