Monitoring of alcohol markers by capillary electrophoresis.

Caslavsky, Jitka; Thormann, Wolfgang (2013). Monitoring of alcohol markers by capillary electrophoresis. Journal of separation science, 36(1), pp. 75-95. Wiley-VCH 10.1002/jssc.201200706

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Work dealing with the monitoring of alcohol markers by CE performed during the past two decades led to the development of assays for carbohydrate-deficient transferrin (CDT), ethyl sulfate, ethyl glucuronide, and phosphatidylethanol in body fluids and first attempts for the detection of the urinary 5-hydroxytryptophol/5-hydroxyindoleacetic acid ratio and stable hemoglobin acetaldehyde adducts. Most notably are assays for CDT that have been commercialized and are being used in many laboratories under routine conditions. This paper provides insight into the development, specifications, and use of the currently known CE-based assays suitable to detect alcohol markers. The achievements reached so far indicate that CE is an attractive technology for monitoring alcohol markers. This is particularly seen with the CDT assays that do not require an elaborate sample pretreatment and thus could be fully automated for high-throughput analyses on multicapillary instruments.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Laboratory for Clinical Pharmacology

UniBE Contributor:

Caslavsky, Jitka and Thormann, Wolfgang

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1615-9306

Publisher:

Wiley-VCH

Language:

English

Submitter:

Wolfgang Thormann

Date Deposited:

25 Jun 2014 16:20

Last Modified:

05 Dec 2014 13:54

Publisher DOI:

10.1002/jssc.201200706

PubMed ID:

23197477

BORIS DOI:

10.7892/boris.53974

URI:

https://boris.unibe.ch/id/eprint/53974

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