Detecting Functional Hubs of Ictogenic Networks

Zubler, Frédéric Alexis Rudolf; Gast, Heidemarie; Abela, Eugenio; Rummel, Christian; Hauf, Martinus; Wiest, Roland; Pollo, Claudio; Schindler, Kaspar Anton (2014). Detecting Functional Hubs of Ictogenic Networks. Brain topography, 28(2), pp. 305-317. Springer 10.1007/s10548-014-0370-x

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Quantitative EEG (qEEG) has modified our understanding of epileptic seizures, shifting our view from the traditionally accepted hyper-synchrony paradigm toward more complex models based on re-organization of functional networks. However, qEEG measurements are so far rarely considered during the clinical decision-making process. To better understand the dynamics of intracranial EEG signals, we examine a functional network derived from the quantification of information flow between intracranial EEG signals. Using transfer entropy, we analyzed 198 seizures from 27 patients undergoing pre-surgical evaluation for pharmaco-resistant epilepsy. During each seizure we considered for each network the in-, out- and total "hubs", defined respectively as the time and the EEG channels with the maximal incoming, outgoing or total (bidirectional) information flow. In the majority of cases we found that the hubs occur around the middle of seizures, and interestingly not at the beginning or end, where the most dramatic EEG signal changes are found by visual inspection. For the patients who then underwent surgery, good postoperative clinical outcome was on average associated with a higher percentage of out- or total-hubs located in the resected area (for out-hubs p = 0.01, for total-hubs p = 0.04). The location of in-hubs showed no clear predictive value. We conclude that the study of functional networks based on qEEG measurements may help to identify brain areas that are critical for seizure generation and are thus potential targets for focused therapeutic interventions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Zubler, Frédéric Alexis Rudolf; Gast, Heidemarie; Abela, Eugenio; Rummel, Christian; Hauf, Martinus; Wiest, Roland; Pollo, Claudio and Schindler, Kaspar Anton

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0896-0267

Publisher:

Springer

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

13 Oct 2014 08:38

Last Modified:

26 Jun 2016 01:53

Publisher DOI:

10.1007/s10548-014-0370-x

PubMed ID:

24846350

BORIS DOI:

10.7892/boris.54017

URI:

https://boris.unibe.ch/id/eprint/54017

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