Jörger Messerli, Marianne; Brühlmann, Esther; Bessire, Anice; Wagner, Anna Margaretha; Mueller, Martin; Surbek, Daniel; Schoeberlein, Andreina (2014). Preeclampsia enhances neuroglial marker expression in umbilical cord Wharton's jelly-derived mesenchymal stem cells. The journal of maternal-fetal & neonatal medicine, 28(4), pp. 464-469. 10.3109/14767058.2014.921671
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Preeclampsia enhances neuroglial marker expression in umbilical cord Wharton s jelly derived mesenchymal stem cells.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB) |
Objective: The aim of the study was to compare the neuroglial phenotype of Wharton's jelly-derived mesenchymal stem cells (WJ-MSC) from pregnancies complicated with preeclampsia and gestational age (GA)-matched controls. Methods: WJ-MSC were isolated from umbilical cords from both groups and analyzed for the cell surface expression of MSC markers and the gene and protein expression of neuroglial markers. Results: All WJ cells were highly positive for the MSC markers CD105, CD90 and CD73, but negative for markers specific for hematopoietic (CD34) and immunological cells (CD45, CD14, CD19 and HLA-DR). WJ-MSC from both groups expressed neuroglial markers (MAP-2, GFAP, MBP, Musashi-1 and Nestin) at the mRNA and protein level. The protein expressions of neuronal (MAP-2) and oligodendrocytic (MBP) markers were significantly increased in WJ-MSC from preeclampsia versus GA-matched controls. Conclusions: WJ-MSC from preeclamptic patients are possibly more committed to neuroglial differentiation through the activation of pathways involved both in the pathophysiology of the disease and in neurogenesis.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pränatale Medizin |
UniBE Contributor: |
Jörger, Marianne, Wagner, Anna Margaretha, Müller, Martin (A), Surbek, Daniel, Schoeberlein, Andreina |
Subjects: |
500 Science 500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1476-4954 |
Language: |
English |
Submitter: |
Monika Zehr |
Date Deposited: |
06 Apr 2016 11:21 |
Last Modified: |
29 Mar 2023 23:34 |
Publisher DOI: |
10.3109/14767058.2014.921671 |
PubMed ID: |
24803009 |
Uncontrolled Keywords: |
Mesenchymal stem cells, Wharton's jelly, neuroglial differentiation, perinatal brain injury, preeclampsia |
BORIS DOI: |
10.7892/boris.54080 |
URI: |
https://boris.unibe.ch/id/eprint/54080 |
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