Preeclampsia enhances neuroglial marker expression in umbilical cord Wharton's jelly-derived mesenchymal stem cells.

Jörger Messerli, Marianne; Brühlmann, Esther; Bessire, Anice; Wagner, Anna Margaretha; Mueller, Martin; Surbek, Daniel; Schoeberlein, Andreina (2014). Preeclampsia enhances neuroglial marker expression in umbilical cord Wharton's jelly-derived mesenchymal stem cells. The journal of maternal-fetal & neonatal medicine, 28(4), pp. 464-469. 10.3109/14767058.2014.921671

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Objective: The aim of the study was to compare the neuroglial phenotype of Wharton's jelly-derived mesenchymal stem cells (WJ-MSC) from pregnancies complicated with preeclampsia and gestational age (GA)-matched controls. Methods: WJ-MSC were isolated from umbilical cords from both groups and analyzed for the cell surface expression of MSC markers and the gene and protein expression of neuroglial markers. Results: All WJ cells were highly positive for the MSC markers CD105, CD90 and CD73, but negative for markers specific for hematopoietic (CD34) and immunological cells (CD45, CD14, CD19 and HLA-DR). WJ-MSC from both groups expressed neuroglial markers (MAP-2, GFAP, MBP, Musashi-1 and Nestin) at the mRNA and protein level. The protein expressions of neuronal (MAP-2) and oligodendrocytic (MBP) markers were significantly increased in WJ-MSC from preeclampsia versus GA-matched controls. Conclusions: WJ-MSC from preeclamptic patients are possibly more committed to neuroglial differentiation through the activation of pathways involved both in the pathophysiology of the disease and in neurogenesis.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pränatale Medizin

UniBE Contributor:

Jörger, Marianne, Wagner, Anna Margaretha, Müller, Martin (A), Surbek, Daniel, Schoeberlein, Andreina


500 Science
500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health






Monika Zehr

Date Deposited:

06 Apr 2016 11:21

Last Modified:

29 Mar 2023 23:34

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Mesenchymal stem cells, Wharton's jelly, neuroglial differentiation, perinatal brain injury, preeclampsia




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