Kallweit, Ulf; Aritake, Kosuke; Bassetti, Claudio; Blumenthal, Stephan; Hayaishi, Osamu; Linnebank, Michael; Baumann, Christian R.; Urade, Yoshihiro (2013). Elevated CSF histamine levels in multiple sclerosis patients. Fluids and barriers of the CNS, 10, p. 19. BioMed Central 10.1186/2045-8118-10-19
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BACKGROUND
Histamine is an ubiquitous inflammatory mediator of numerous physiological processes. Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis. We prospectively enrolled 36 MS patients and 19 age and gender-matched healthy volunteers for cerebrospinal fluid (CSF) histamine analysis.
FINDINGS
CSF HISTAMINE LEVELS IN MS PATIENT SAMPLES WERE SIGNIFICANTLY HIGHER (MEDIAN: 35.6 pg/ml) than in controls (median: 5.5 pg/ml; Beta = 0.525, p < 0.001). In addition, histamine increased with age (Pearson's correlation, p < 0.003).
CONCLUSIONS
Histamine may be an important factor for both the initiation and maintenance of chronic inflammatory diseases of the central nervous system. Our observation encourages a deeper investigation of the role of histamine in MS.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Bassetti, Claudio L.A. |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2045-8118 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Valentina Rossetti |
Date Deposited: |
30 Jun 2014 14:58 |
Last Modified: |
02 Mar 2023 23:25 |
Publisher DOI: |
10.1186/2045-8118-10-19 |
PubMed ID: |
23659456 |
Uncontrolled Keywords: |
Multiple sclerosis, Histamine, Histamine receptors, CSF, Granulocyte-macrophage colony-stimulating factor, Chronic inflammatory diseases |
BORIS DOI: |
10.7892/boris.54135 |
URI: |
https://boris.unibe.ch/id/eprint/54135 |
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