Elevated CSF histamine levels in multiple sclerosis patients.

Kallweit, Ulf; Aritake, Kosuke; Bassetti, Claudio; Blumenthal, Stephan; Hayaishi, Osamu; Linnebank, Michael; Baumann, Christian R.; Urade, Yoshihiro (2013). Elevated CSF histamine levels in multiple sclerosis patients. Fluids and barriers of the CNS, 10, p. 19. BioMed Central 10.1186/2045-8118-10-19

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BACKGROUND Histamine is an ubiquitous inflammatory mediator of numerous physiological processes. Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis. We prospectively enrolled 36 MS patients and 19 age and gender-matched healthy volunteers for cerebrospinal fluid (CSF) histamine analysis. FINDINGS CSF HISTAMINE LEVELS IN MS PATIENT SAMPLES WERE SIGNIFICANTLY HIGHER (MEDIAN: 35.6 pg/ml) than in controls (median: 5.5 pg/ml; Beta = 0.525, p < 0.001). In addition, histamine increased with age (Pearson's correlation, p < 0.003). CONCLUSIONS Histamine may be an important factor for both the initiation and maintenance of chronic inflammatory diseases of the central nervous system. Our observation encourages a deeper investigation of the role of histamine in MS.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Bassetti, Claudio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2045-8118

Publisher:

BioMed Central

Language:

English

Submitter:

Valentina Rossetti

Date Deposited:

30 Jun 2014 14:58

Last Modified:

04 Dec 2014 18:57

Publisher DOI:

10.1186/2045-8118-10-19

PubMed ID:

23659456

Uncontrolled Keywords:

Multiple sclerosis, Histamine, Histamine receptors, CSF, Granulocyte-macrophage colony-stimulating factor, Chronic inflammatory diseases

BORIS DOI:

10.7892/boris.54135

URI:

https://boris.unibe.ch/id/eprint/54135

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