Correlation between altered central pain processing and concentration of peritoneal fluid inflammatory cytokines in endometriosis patients with chronic pelvic pain

Neziri, Alban Y; Bersinger, Nick A.; Andersen, Ole K; Arendt-Nielsen, Lars; Mueller, Michael; Curatolo, Michele (2014). Correlation between altered central pain processing and concentration of peritoneal fluid inflammatory cytokines in endometriosis patients with chronic pelvic pain. Regional anesthesia and pain medicine, 39(3), pp. 181-184. Lippincott Williams & Wilkins 10.1097/AAP.0000000000000068

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Translational research has not yet elucidated whether alterations in central pain processes are related to peripheral inflammatory processes in chronic pain patients. We tested the hypothesis that the concentration of cytokines in the peritoneal fluid of endometriosis patients with chronic pain correlate with parameters of hyperexcitability of the nociceptive system. The concentrations of 15 peritoneal fluid cytokines were measured in 11 patients with chronic pelvic pain and a diagnosis of endometriosis. Six parameters assessing central pain processes were recorded. Positive correlations between concentration of some cytokines in the peritoneal fluid and amplification of central pain processing were found. The results suggest that inflammatory mechanisms may be important in the pathophysiology of altered central pain processes and that cytokines produced in the environment of endometriosis could act as mediators between the peripheral lesion and changes in central nociceptive processes.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Bersinger, Nick A. and Mueller, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1098-7339

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Nathalie Ursula Becher

Date Deposited:

13 Oct 2014 09:30

Last Modified:

21 Oct 2015 12:00

Publisher DOI:

10.1097/AAP.0000000000000068

PubMed ID:

24694998

BORIS DOI:

10.7892/boris.54188

URI:

https://boris.unibe.ch/id/eprint/54188

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