Lavallée, Philippa C.; Labreuche, Julien; Fox, Kim M.; Lavados, Pablo; Mattle, Heinrich; Steg, Philippe Gabriel; Amarenco, Pierre (2014). Influenza vaccination and cardiovascular risk in patients with recent TIA and stroke. Neurology, 82(21), pp. 1905-1913. Lippincott Williams & Wilkins 10.1212/WNL.0000000000000456
|
Text
Lavallée-1905-13Neurology-2014.pdf - Published Version Available under License Publisher holds Copyright. Download (592kB) | Preview |
OBJECTIVES: To determine whether current influenza vaccination is associated with reduced risk of major vascular events in patients with recent ischemic stroke or TIA of mainly atherothrombotic origin. METHODS: Data were pooled from 2 prospective cohort studies, the OPTIC Registry (n = 3,635) and the AMISTAD Study (n = 618), and from the randomized PERFORM Trial (n = 19,120), all of which included patients with recent ischemic stroke or TIA. Influenza vaccination status was determined in 23,110 patients. The primary outcome was a composite of nonfatal myocardial infarction, nonfatal stroke, or vascular death up to 2 years. Secondary outcomes were myocardial infarction and stroke separately. RESULTS: Influenza vaccination had no association with the primary outcome in the propensity score-matched cohort (hazard ratio 0.97, 95% confidence interval [CI] 0.85-1.11; p = 0.67) or in the propensity score-adjusted cohort (hazard ratio 1.00, 95% CI 0.89-1.12; p = 0.99). Similarly, the risk of stroke and myocardial infarction did not differ between the vaccinated group and the unvaccinated group; in the matched cohort, the hazard ratio was 1.01 (95% CI 0.88-1.17; p = 0.89) for stroke and 0.84 (95% CI 0.59-1.18; p = 0.30) for myocardial infarction. CONCLUSIONS: Influenza vaccination was not associated with reduced outcome events in patients with recent atherothrombotic ischemic stroke after considering all baseline characteristics (including concomitant medications) associated with influenza vaccination.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Mattle, Heinrich |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0028-3878 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Valentina Rossetti |
Date Deposited: |
12 Sep 2014 09:21 |
Last Modified: |
05 Dec 2022 14:35 |
Publisher DOI: |
10.1212/WNL.0000000000000456 |
PubMed ID: |
24789867 |
BORIS DOI: |
10.7892/boris.54201 |
URI: |
https://boris.unibe.ch/id/eprint/54201 |
Actions (login required)
 |
Edit item |