Experimental validation of a mean field model of mineralized collagen fiber arrays at two levels of hierarchy

Spiesz, Eva M.; Reisinger, Andreas G.; Roschger, Paul; Zysset, Philippe (2014). Experimental validation of a mean field model of mineralized collagen fiber arrays at two levels of hierarchy. Journal of Mechanics in Medicine and Biology, 14(02), p. 1450013. World Scientific Publishing Co. 10.1142/S0219519414500134

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In the course of this study, stiffness of a fibril array of mineralized collagen fibrils modeled with a mean field method was validated experimentally at site-matched two levels of tissue hierarchy using mineralized turkey leg tendons (MTLT). The applied modeling approaches allowed to model the properties of this unidirectional tissue from nanoscale (mineralized collagen fibrils) to macroscale (mineralized tendon). At the microlevel, the indentation moduli obtained with a mean field homogenization scheme were compared to the experimental ones obtained with microindentation. At the macrolevel, the macroscopic stiffness predicted with micro finite element (μFE) models was compared to the experimental stiffness measured with uniaxial tensile tests. Elastic properties of the elements in μFE models were injected from the mean field model or two-directional microindentations. Quantitatively, the indentation moduli can be properly predicted with the mean-field models. Local stiffness trends within specific tissue morphologies are very weak, suggesting additional factors responsible for the stiffness variations. At macrolevel, the μFE models underestimate the macroscopic stiffness, as compared to tensile tests, but the correlations are strong.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB

UniBE Contributor:

Zysset, Philippe


500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health




World Scientific Publishing Co.




Regula Schatzmann

Date Deposited:

02 Jul 2014 13:58

Last Modified:

26 Jun 2016 01:53

Publisher DOI:




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