Dusty punch cards and an eternal enigma: high-density lipoproteins and atherosclerosis

Kleber, Marcus E.; Grammer, Tanja B.; Kassner, Ursula; Silbernagel, Günther; März, Winfried (2014). Dusty punch cards and an eternal enigma: high-density lipoproteins and atherosclerosis. Drugs, 74(5), pp. 513-520. Adis International 10.1007/s40265-014-0189-5

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Epidemiological, clinical, and experimental evidence has accumulated during the last decades suggesting that high-density lipoproteins (HDLs) may protect from atherosclerosis and its clinical consequences. However, more than 55 years after the first description of the link between HDL and heart attacks, many facets of the biochemistry, function, and clinical significance of HDL remain enigmatic. This applies particularly to the completely unexpected results that became available from some recent clinical trials of nicotinic acid and of inhibitors of cholesteryl ester transfer protein (CETP). The concept that raising HDL cholesterol by pharmacological means would decrease the risk of vascular disease has therefore been challenged.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Silbernagel, Günther

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0012-6667

Publisher:

Adis International

Language:

English

Submitter:

Catherine Gut

Date Deposited:

13 Oct 2014 14:19

Last Modified:

30 Oct 2015 07:37

Publisher DOI:

10.1007/s40265-014-0189-5

PubMed ID:

24691706

BORIS DOI:

10.7892/boris.54478

URI:

https://boris.unibe.ch/id/eprint/54478

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