Prognostic relevance of Bcl-2 overexpression in surgically treated prostate cancer is not caused by increased copy number or translocation of the gene

Fleischmann, A; Huland, H; Mirlacher, M; Wilczak, W; Simon, R; Erbersdobler, A; Sauter, G; Schlomm, T (2012). Prognostic relevance of Bcl-2 overexpression in surgically treated prostate cancer is not caused by increased copy number or translocation of the gene. Prostate, 72(9), pp. 991-7. Hoboken, N.J.: Wiley-Blackwell 10.1002/pros.21504

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Overexpression of anti-apoptotic Bcl-2 plays a role in prostate cancer progression, particularly in transformation to androgen-independent disease. Androgen-independent prostate cancers have been shown to harbor Bcl-2 gene copy number gains frequently suggesting that this genetic alteration might play a role in Bcl-2 overexpression. The relation of Bcl-2 overexpression and copy number gains or translocation of the BCL-2 gene in prostate cancer under hormone-naïve conditions is unknown.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Fleischmann, Achim

ISSN:

0270-4137

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:18

Last Modified:

17 Mar 2015 19:23

Publisher DOI:

10.1002/pros.21504

PubMed ID:

22024950

Web of Science ID:

000303918300008

URI:

https://boris.unibe.ch/id/eprint/5476 (FactScience: 210223)

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