Whole genome scan identifies several chromosomal regions linked to equine sarcoids.

Jandova, Vendula; Klukowska-Rötzler, J; Dolf, Gaudenz; Janda, Jozef; Roosje, Petra; Marti, E; Koch, Christoph; Gerber, Vinzenz; Swinburne, J (2012). Whole genome scan identifies several chromosomal regions linked to equine sarcoids. Schweizer Archiv für Tierheilkunde, 154(1), pp. 19-25. 10.1024/0036-7281/a000288

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Despite the evidence for a genetic predisposition to develop equine sarcoids (ES), no whole genome scan for ES has been performed to date. The objective of this explorative study was to identify chromosome regions associated with ES. The studied population was comprised of two half-sibling sire families, involving a total of 222 horses. Twenty-six of these horses were affected with ES. All horses had been previously genotyped with 315 microsatellite markers. Quantitative trait locus (QTL) signals were suggested where the F statistic exceeded chromosome-wide significance at P < 0.05. The QTL analyses revealed significant signals reaching P < 0.05 on equine chromosome (ECA) 20, 23 and 25, suggesting a polygenic character for this trait. The candidate regions identified on ECA 20, 23 and 25 include genes regulating virus replication and host immune response. Further investigation of the chromosome regions associated with ES and of genes potentially responsible for the development of ES could form the basis for early identification of susceptible animals, breeding selection or the development of new therapeutic targets.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Dermatology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Jandova, Vendula; Dolf, Gaudenz; Janda, Jozef; Roosje, Petra; Koch, Christoph and Gerber, Vinzenz

Subjects:

600 Technology > 630 Agriculture

ISSN:

0036-7281

Language:

English

Submitter:

Tamara Leuenberger

Date Deposited:

28 Jul 2014 15:41

Last Modified:

17 Aug 2018 15:20

Publisher DOI:

10.1024/0036-7281/a000288

PubMed ID:

22222899

URI:

https://boris.unibe.ch/id/eprint/55032

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