Molecular epidemiology of tuberculosis in Cambodian children

Schopfer, K; Rieder, H L; Steinlin-Schopfer, J F; van Soolingen, D; Bodmer, T; Chantana, Y; Studer, P; Laurent, D; Zwahlen, M; Richner, B (2015). Molecular epidemiology of tuberculosis in Cambodian children. Epidemiology and infection, 143(5), pp. 910-21. Cambridge University Press 10.1017/S0950268814001769

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SUMMARY We analysed Mycobacterium tuberculosis strains from children, hospitalized from January 2004 to July 2008 in the largest paediatric hospital complex in Cambodia. Specimens were tested for drug susceptibility and genotypes. From the 260 children, 161 strains were available. The East African-Indian genotype family was the most common (59·0%), increasing in frequency with distance from the Phnom Penh area, while the frequency of the Beijing genotype family strains decreased. The drug resistance pattern showed a similar geographical gradient: lowest in the northwest (4·6%), intermediate in the central (17·1%), and highest in the southeastern (30·8%) parts of the country. Three children (1·9%) had multidrug-resistant tuberculosis. The Beijing genotype and streptomycin resistance were significantly associated (P < 0·001). As tuberculosis in children reflects recent transmission patterns in the community, multidrug resistance levels inform about the current quality of the tuberculosis programme.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Schopfer, Kurt; Steinlin, Jacqueline; Bodmer, Thomas and Zwahlen, Marcel

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services
500 Science > 570 Life sciences; biology

ISSN:

0950-2688

Publisher:

Cambridge University Press

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

15 Oct 2014 07:05

Last Modified:

01 Apr 2020 02:30

Publisher DOI:

10.1017/S0950268814001769

PubMed ID:

25050615

BORIS DOI:

10.7892/boris.55049

URI:

https://boris.unibe.ch/id/eprint/55049

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