What a unicellular parasite can tell us about mitochondrial biogenesis?

Schneider, André (25 September 2013). What a unicellular parasite can tell us about mitochondrial biogenesis? (Unpublished). In: What a unicellular parasite can tell us about mitochondrial biogenesis?. Universität Köln. 25.09.2013.

Most of what we know about mitochondrial biogenesis stems from work in yeast and mammals, which are quite closely related. To understand the conserved features of mitochondria and the evolutionary forces that shaped it, it is important to study a more diverse group of eukaryotes. The parasitic protozoan Trypanosoma brucei and its relatives are excellent systems to do so, since they appear to have diverged from other eukaryotes very early in evolution. This is reflected in a number of unique and extreme features in their mitochondrial biology, including a single continuous mitochondrion that contains a one unit mitochondrial genome that is physically connected across the two membranes with the basal body of the flagellum. Moreover, many mitochondrial transcripts have to be extensively edited in order to become functional mRNAs and organellar translation requires extensive import of cytosolic tRNAs.
In my talk I will focus on the discovery and characterization of the elusive mitochondrial protein import system of the mitochondrial outer membrane of trypanosomes. In addition I will present data on a central outer membrane component of the mitochondrial genome inheritance system of T. brucei and compare it to the better characterized system of yeast. - I hope that I can convince you in my talk, that a better understanding of the mitochondrial biology in T. brucei will provide insights into both fundamentally conserved and fundamentally diverged aspects of mitochondrial biogenesis and thus of the evolutionary hstory of mitochondria in general.

Item Type:

Conference or Workshop Item (Speech)


08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

UniBE Contributor:

Schneider, André


500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry




Christina Schüpbach

Date Deposited:

30 Jul 2014 16:41

Last Modified:

05 Dec 2022 14:36



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