Expression of adipokines and estrogen receptors in adipose tissue and placenta of patients with gestational diabetes mellitus

Kleiblova, P; Dostalova, I; Bartlova, M; Lacinova, Z; Ticha, I; Krejci, V; Springer, D; Kleibl, Z; Haluzik, M (2010). Expression of adipokines and estrogen receptors in adipose tissue and placenta of patients with gestational diabetes mellitus. Molecular and cellular endocrinology, 314(1), pp. 150-6. Shannon: Elsevier Ireland 10.1016/j.mce.2009.08.002

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The purpose of this study was to assess the expression profile of genes with potential role in the development of insulin resistance (adipokines, cytokines/chemokines, estrogen receptors) in subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT) and placenta of pregnant women with gestational diabetes mellitus (GDM) and age-matched women with physiological pregnancy at the time of Caesarean section. qRT-PCR was used for expression analysis of the studied genes. Leptin gene expression in VAT of GDM group was significantly higher relative to control group. Gene expressions of interleukin-6 and interleukin-8 were significantly increased, whereas the expressions of genes for estrogen receptors alpha and beta were significantly reduced in SAT of GDM group relative to controls, respectively. We found no significant differences in the expression of any genes of interest (LEP, RETN, ADIPOR1, ADIPOR2, TNF-alpha, CD68, IL-6, IL-8, ER alpha, ER beta) in placentas of women with GDM relative to controls. We conclude that increased expression of leptin in visceral adipose depot together with increased expressions of proinflammatory cytokines and reduced expressions of estrogen receptors in subcutaneous fat may play a role in the etiopathogenesis of GDM.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

UniBE Contributor:

Krejci, Vladimir

ISSN:

0303-7207

Publisher:

Elsevier Ireland

Language:

English

Submitter:

Jeannie Wurz

Date Deposited:

04 Oct 2013 14:08

Last Modified:

23 Jan 2018 12:17

Publisher DOI:

10.1016/j.mce.2009.08.002

PubMed ID:

19682537

Web of Science ID:

000272101700018

URI:

https://boris.unibe.ch/id/eprint/554 (FactScience: 199727)

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