Relative Contributions of Osteogenic Tissues to New Bone Formation in Periosteal Distraction Osteogenesis: Histological and Histomorphometrical Evaluation in a Rat Calvaria

Saulacic, Nikola; Hug, Cladius; Bosshardt, Dieter; Schaller, Benoit; Buser, Daniel; Haeniwa, Hideya; Iizuka, Tateyuki (2013). Relative Contributions of Osteogenic Tissues to New Bone Formation in Periosteal Distraction Osteogenesis: Histological and Histomorphometrical Evaluation in a Rat Calvaria. Clinical implant dentistry and related research, 15(5), pp. 692-706. Oxford: Blackwell 10.1111/j.1708-8208.2011.00400.x

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Background: The relative contributions of different, potential factors to new bone formation in periosteal distraction osteogenesis are unknown. Purpose: The aim of the present study was to assess the influence of original bone and periosteum on bone formation during periosteal distraction osteogenesis in a rat calvarial model by means of histology and histomorphometry. Methods: A total of 48 rats were used for the experiment. The contribution of the periosteum was assessed by either intact or incised periosteum or an occlusive versus a perforated distraction plate. The cortical bone was either left intact or perforated. Animals were divided in eight experimental groups considering the three possible treatment modalities. All animals were subjected to a 7-day latency period, a 10-day distraction period and a 7-day consolidation period. The newly formed bone was analyzed histologically and histomorphometrically. Results: New, mainly woven bone was found in all groups. Differences in the maximum height of new bone were observed and depended on location. Under the distraction plate, statistically significant differences in maximum bone height were found between the group with perforations in both cortical bone and distraction plate and the group without such perforations. Conclusions: If the marrow cavities were not opened, the contribution to new bone formation was dominant from the periosteum. If the bone perforations opened the marrow cavities, a significant contribution to new bone formation originated from the native bone.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Oral Surgery and Stomatology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery

UniBE Contributor:

Saulacic, Nikola; Bosshardt, Dieter; Schaller, Benoît; Buser, Daniel; Haeniwa, Hideya and Iizuka, Tateyuki

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1523-0899

Publisher:

Blackwell

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

04 Oct 2013 14:18

Last Modified:

25 Jan 2017 12:15

Publisher DOI:

10.1111/j.1708-8208.2011.00400.x

PubMed ID:

22098938

BORIS DOI:

10.7892/boris.5641

URI:

https://boris.unibe.ch/id/eprint/5641 (FactScience: 210422)

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