Multi-modal diffeomorphic demons registration based on point-wise mutual information

Lu, Huanxiang; Reyes, Mauricio; Šerifović, Amira; Weber, Stefan; Sakurai, Yasuo; Yamagata, Hitoshi; Cattin, Philippe C. (April 2010). Multi-modal diffeomorphic demons registration based on point-wise mutual information. In: ISBI'10: Proceedings of the 2010 IEEE international conference on Biomedical imaging (pp. 372-375). IEEE 10.1109/ISBI.2010.5490333

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In this paper we propose a variational approach for multimodal image registration based on the diffeomorphic demons algorithm. Diffeomorphic demons has proven to be a robust and efficient way for intensity-based image registration. However, the main drawback is that it cannot deal with multiple modalities. We propose to replace the standard demons similarity metric (image intensity differences) by point-wise mutual information (PMI) in the energy function. By comparing the accuracy between our PMI based diffeomorphic demons and the B-Spline based free-form deformation approach (FFD) on simulated deformations, we show the proposed algorithm performs significantly better.

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