Baseline hypovitaminosis D is not associated with poor clinical outcomes in osteoarticular infections

Marschall, Jonas; Lewis, J W S; Warren, D K; Babcock, H M; Barrack, R L; Fraser, V J (2014). Baseline hypovitaminosis D is not associated with poor clinical outcomes in osteoarticular infections. International journal of infectious diseases, 26, pp. 98-102. Elsevier 10.1016/j.ijid.2014.05.004

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OBJECTIVES Although vitamin D is recognized as an important factor in bone health, its role in osteoarticular infections is unclear. We hypothesized that low vitamin D (25-hydroxycholecalciferol) levels are associated with a lower likelihood of treatment success in osteoarticular infections. METHODS This was a retrospective cohort study of patients with orthopedic infections who had a 25-hydroxycholecalciferol level drawn when their infection was diagnosed. Outcomes were determined at early (3-6 months) and late (≥6 months) follow-up after completing intravenous antibiotics. RESULTS We included 223 patients seen during an 11-month period with osteoarticular infections and baseline 25-hydroxycholecalciferol levels. During the initial inpatient management of the infection, hypovitaminosis D was identified and treated. The mean 25-hydroxycholecalciferol level was 23±14ng/ml; 167 (75%) patients had levels <30ng/ml. Overall, infection treatment success was 91% (159/174) at early follow-up and 88% (145/164) at late follow-up. 25-Hydroxycholecalciferol baseline levels were similar in those with and without successful clinical outcomes, both at early (25±15 vs. 21±9ng/ml; p=0.3) and late follow-up (25±15 vs. 23±16ng/ml; p=0.6). CONCLUSIONS To our knowledge this is the first report on hypovitaminosis D and its impact on outcomes of osteoarticular infections. Hypovitaminosis D was frequent in this cohort. With vitamin D repletion, there was no difference in treatment success whether patients had baseline hypovitaminosis or not.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Marschall, Jonas


600 Technology > 610 Medicine & health








Annelies Luginbühl

Date Deposited:

14 Oct 2014 10:31

Last Modified:

09 May 2019 15:12

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Cholecalciferol, Joint infection, Osteomyelitis, Outcome, Vitamin D




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