Therapie und Prävention von opportunistischen Infektionen

Staehelin, Cornelia Johanna; Elzi, Luigia; Weber, Rainer; Furrer, Hansjakob (2014). Therapie und Prävention von opportunistischen Infektionen. Therapeutische Umschau, 71(8), pp. 475-482. Huber 10.1024/0040-5930/a000540

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Incidence as well as morbidity and mortality of opportunistic infections (OI) have declined remarkably since the availability of antiretroviral treatment (ART). Nearly half of all persons infected with HIV however do not know their HIV-status, and the diagnosis of an OI may be the first manifestation of their HIV infection. Therefore, knowledge of the presentation of OIs as well as their management should remain an essential part of clinicians' expertise. After starting ART the immune system will improve; in this context OI may be unmasked or the clinical presentation of known OI may worsen. Before starting ART therefore, it is essential to rule out any asymptomatic or latent OI. For the same reason, in the case of a known OI, the start of ART must often be deferred for some weeks after the start of OI treatment. Treatment of OIs is complex and often results in a large pill-burden for the patient with the potential for multiple drug-drug-interactions, particularly once ART has to be started. Many of the OI treatments are also associated with frequent drug side-effects and allergies. OIs can be prevented with specific antimicrobial agents once the CD4 have decreased below a defined threshold. However, the main prevention of OI is the timely recognition of HIV infection and an early start of ART before complications of OI appear.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Staehelin, Cornelia Johanna and Furrer, Hansjakob

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0040-5930

Publisher:

Huber

Language:

German

Submitter:

Annelies Luginbühl

Date Deposited:

14 Oct 2014 10:52

Last Modified:

19 Oct 2015 11:11

Publisher DOI:

10.1024/0040-5930/a000540

PubMed ID:

25093312

BORIS DOI:

10.7892/boris.58158

URI:

https://boris.unibe.ch/id/eprint/58158

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