Enhancement of bone healing using non-glycosylated rhBMP-2 released from a fibrin matrix in dogs and cats

Schmökel, Hugo; Weber, F. E.; Hurter, K.; Schense, J. C.; Seiler, Gabriela; Rytz, Ulrich; Spreng, David; Schawalder, Peter; Hubbell, J. (2005). Enhancement of bone healing using non-glycosylated rhBMP-2 released from a fibrin matrix in dogs and cats. Journal of small animal practice, 46(1), pp. 17-21. Pergamon Press

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OBJECTIVES To test a non-glycosylated recombinant human bone morphogenetic protein-2 (ngly-rhBMP-2)/fibrin composite, which has been shown experimentally to enhance healing of bone defects in rodents, in a clinical case series of dogs and cats undergoing treatment for fracture non-unions and arthrodesis. METHODS A ngly-rhBMP-2/fibrin composite was applied in 41 sites in 38 dogs and cats for which a cancellous bone autograft was indicated, replacing the graft. RESULTS Bridging of the bone defect with functional bone healing was achieved in 90 per cent of the arthrodesis and fracture nonunions treated in this manner. CLINICAL SIGNIFICANCE This prospective clinical study demonstrates the beneficial effects of ngly-rhBMP-2 in a specially designed fibrin matrix on the treatment of bone defects, and validates the use of this composite as an alternative to bone autografts in dogs and cats.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Surgery
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Radiology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic

UniBE Contributor:

Schmökel, Hugo; Seiler, Gabriela; Rytz, Ulrich; Spreng, David and Schawalder, Peter

Subjects:

600 Technology > 630 Agriculture

ISSN:

0022-4510

Publisher:

Pergamon Press

Language:

English

Submitter:

Simone Forterre

Date Deposited:

24 Sep 2014 15:14

Last Modified:

25 Dec 2014 01:14

PubMed ID:

15682735

BORIS DOI:

10.7892/boris.58579

URI:

https://boris.unibe.ch/id/eprint/58579

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