Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis

Borer, Luc R.; Peel, John E.; Seewald, Wolfgang; Schawalder, Peter; Spreng, David (2003). Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis. American journal of veterinary research, 64(11), pp. 1429-1437. American Veterinary Medical Association

[img] Text
ajvr.2003.64.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (151kB) | Request a copy

OBJECTIVE: To compare the analgesic and anti-inflammatory effect of single doses of carprofen, etodolac, meloxicam, and butorphanol in dogs with induced acute synovitis (acute pain model) via kinetic gait analysis and orthopedic evaluation and examine measurement of serum C-reactive protein (CRP) concentration as an indicator of treatment efficacy. ANIMALS: 12 Beagles and 6 additional Beagles that were used only in serum CRP analyses. PROCEDURE: Acute synovitis was induced in right stifle joints of dogs via intra-articular injection of monosodium urate solution. Treatments included butorphanol (0.2 mg/kg, i.v.), carprofen (4 mg/kg, PO), etodolac (17 mg/kg, PO), or meloxicam (0.2 mg/kg, PO); control dogs received no treatment. The procedure was repeated (3-week intervals) until all dogs received all treatments including control treatment. Lameness was assessed on a biomechanical force platform and via orthopedic evaluations of the stifle joints; blood was collected to monitor serum CRP concentration. RESULTS: Compared with control dogs, treated dogs had significantly different vertical ground reaction forces and weight-bearing scores. Greatest improvement in lameness was observed in carprofen-treated dogs. Etodolac had the fastest onset of action. Compared with butorphanol treatment, only carprofen and etodolac were associated with significantly lower pain scores. An increase in serum CRP concentration was detected after intra-articular injection in all dogs; this change was similar among groups. CONCLUSIONS AND CLINICAL RELEVANCE: Carprofen, etodolac, and meloxicam had greater efficacy than butorphanol in relief of acute pain. Carprofen was most effective overall. In this acute pain model, serum CRP analysis was not useful to assess drug efficacy.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Surgery

UniBE Contributor:

Schawalder, Peter and Spreng, David

Subjects:

600 Technology > 630 Agriculture
500 Science

ISSN:

0002-9645

Publisher:

American Veterinary Medical Association

Language:

English

Submitter:

Simone Forterre

Date Deposited:

26 Sep 2014 08:58

Last Modified:

08 Feb 2016 16:54

PubMed ID:

14620781

BORIS DOI:

10.7892/boris.58587

URI:

https://boris.unibe.ch/id/eprint/58587

Actions (login required)

Edit item Edit item
Provide Feedback