Allograft Survival with Calcineurin Inhibitors

Jones, Neil F.; Vögelin, Esther (2008). Allograft Survival with Calcineurin Inhibitors. In: Hewitt, Charles W.; Lee, Andrew W. P.; Gordon, Chad R. (eds.) Transplantation of Composite Tissue Allografts (pp. 121-149). New York: Springer 10.1007/978-0-387-74682-1_10

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The immunosuppressive drugs cyclosporine A (CsA) and tacrolimus (FK506), also called calcineurin inhibitors, have truly revolutionized allograft transplantation. The introduction of CsA in 1976 was the first major advance in transplantation since the introduction of prednisone and azathioprine made allograft transplantation possible in the early 1950s and 1960s. FK506 was approved in 1994 and led to dramatic improvements in solid organ transplantation, allowing highly antigenic lymph node bearing allografts, such as the small bowel, to be transplanted. Recently, FK506 monotherapy has successfully allowed combined small bowel and partial abdominal wall transplantation in humans. The success of FK506 and CsA has made them key drugs in the modern era of transplantation. The purine synthesis inhibitor mycophenolate mofetil (MMF) was approved in 1995, and the drug Sirolimus (rapamycin) was introduced in 1999. Combining these drugs with calcineurin inhibitors has significantly reduced the incidence of acute rejection and improved solid organ allograft survival, with a reduction in adverse effects.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery > Hand Surgery
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery

UniBE Contributor:

Vögelin, Esther

Subjects:

600 Technology > 610 Medicine & health

ISBN:

978-0-387-74681-4

Publisher:

Springer

Language:

English

Submitter:

Jörg Arnoldi

Date Deposited:

11 Sep 2014 16:38

Last Modified:

05 Jan 2015 00:46

Publisher DOI:

10.1007/978-0-387-74682-1_10

Uncontrolled Keywords:

Immunology, Surgery, Transplant Surgery, Biomedical Engineering

BORIS DOI:

10.7892/boris.58674

URI:

https://boris.unibe.ch/id/eprint/58674

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