Role of Na/H exchange in insulin secretion by islet cells

Deisl, Christine; Albano, Giuseppe; Fuster, Daniel Guido (2014). Role of Na/H exchange in insulin secretion by islet cells. Current Opinion in Nephrology and Hypertension, 23(4), pp. 406-410. Lippincott Williams & Wilkins 10.1097/01.mnh.0000447013.36475.96

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PURPOSE OF REVIEW: Sodium/hydrogen exchangers (NHEs) are a large family of transport proteins catalyzing the exchange of cations for protons across lipid bilayer membranes. Several isoforms are expressed in β cells of the endocrine pancreas, including the recently discovered and poorly characterized isoform NHA2. This review will summarize advances in our understanding of the roles of NHEs in the regulation of insulin secretion in β cells. RECENT FINDINGS: Plasmalemmal full-length NHE1 defends β cells from intracellular acidification, but has no role in stimulus-secretion coupling and is not causally involved in glucose-induced alkalinization of the β cell. The function of a shorter NHE1 splice variant, which localizes to insulin-containing large dense core vesicles, remains currently unknown. In contrast, in-vitro and in-vivo studies indicate that the NHA2 isoform is required for insulin secretion and clathrin-mediated endocytosis in β cells. SUMMARY: Recent data highlight the importance of NHEs in the regulation of cellular pH, clathrin-mediated endocytosis and insulin secretion in β cells. Based on these studies, a pathophysiological role of NHEs in human disorders of the endocrine pancreas seems likely and should be investigated.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Nephrologie / Hypertonie
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Deisl, Christine; Albano, Giuseppe and Fuster, Daniel Guido

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1062-4821

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Daniel Guido Fuster

Date Deposited:

13 Oct 2014 12:04

Last Modified:

19 Jan 2016 12:56

Publisher DOI:

10.1097/01.mnh.0000447013.36475.96

PubMed ID:

24840298

BORIS DOI:

10.7892/boris.58699

URI:

https://boris.unibe.ch/id/eprint/58699

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