Biomechanical model of human cornea based on stromal microstructure

Studer, H; Larrea, X; Riedwyl, H; Büchler, P (2010). Biomechanical model of human cornea based on stromal microstructure. Journal of biomechanics, 43(5), p. 836. New York, N.Y.: Elsevier 10.1016/j.jbiomech.2009.11.021

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The optical characteristics of the human cornea depends on the mechanical balance between the intra-ocular pressure and intrinsic tissue stiffness. A wide range of ophthalmic surgical procedures alter corneal biomechanics to induce local or global curvature changes for the correction of visual acuity. Due to the large number of surgical interventions performed every day, a deeper understanding of corneal biomechanics is needed to improve the safety of these procedures and medical devices. The aim of this study is to propose a biomechanical model of the human cornea, based on stromal microstructure. The constitutive mechanical law includes collagen fiber distribution based on X-ray scattering analysis, collagen cross-linking, and fiber uncrimping. Our results showed that the proposed model reproduced inflation and extensiometry experimental data [Elsheikh et al., Curr. Eye Res., 2007; Elsheikh et al., Exp. Eye Res., 2008] successfully. The mechanical properties obtained for different age groups demonstrated an increase in collagen cross-linking for older specimens. In future work such a model could be used to simulate non-symmetric interventions, and provide better surgical planning.

Item Type:	Journal Article (Original Article)
Division/Institute:	10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Computational Bioengineering 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB [discontinued]
UniBE Contributor:	Studer, Harald, Büchler, Philippe
ISSN:	0021-9290
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:08
Last Modified:	27 Jun 2024 11:28
Publisher DOI:	10.1016/j.jbiomech.2009.11.021
Web of Science ID:	000276711700004
URI:	https://boris.unibe.ch/id/eprint/587 (FactScience: 199837)