Sensory innervation of the dorsal longitudinal ligament and the meninges in the lumbar spine of the dog

Waber-Wenger, Barbara; Forterre, Franck; Kuehni-Boghenbor, Kathrin; Danuser, Renzo; Stein, Jens Volker; Stoffel, Michael Hubert (2014). Sensory innervation of the dorsal longitudinal ligament and the meninges in the lumbar spine of the dog. Histochemistry and cell biology, 142(4), pp. 433-447. Springer 10.1007/s00418-014-1218-x

[img] Text
art%3A10.1007%2Fs00418-014-1218-x.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

Although intervertebral disc herniation is a well-known disease in dogs, pain management for this condition has remained a challenge. The goal of the present study is to address the lack of information regarding the innervation of anatomical structures within the canine vertebral canal. Immunolabeling was performed with antibodies against protein gene product 9.5, Tuj-1 (neuron-specific class III β-tubulin), calcitonin gene-related peptide, and neuropeptide Y in combination with the lectin from Lycopersicon esculentum as a marker for blood vessels. Staining was indicative of both sensory and sympathetic fibers. Innervation density was the highest in lateral areas, intermediate in dorsal areas, and the lowest in ventral areas. In the dorsal longitudinal ligament (DLL), the highest innervation density was observed in the lateral regions. Innervation was lower at mid-vertebral levels than at intervertebral levels. The presence of sensory and sympathetic fibers in the canine dura and DLL suggests that pain may originate from both these structures. Due to these regional differences in sensory innervation patterns, trauma to intervertebral DLL and lateral dura is expected to be particularly painful. The results ought to provide a better basis for the assessment of medicinal and surgical procedures.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > NeuroCenter
04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Surgery
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Anatomy
09 Interdisciplinary Units > Microscopy Imaging Center (MIC)

UniBE Contributor:

Waber-Wenger, Barbara; Forterre, Franck; Kühni, Kathrin; Danuser, Renzo; Stein, Jens Volker and Stoffel, Michael Hubert

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

0948-6143

Publisher:

Springer

Language:

English

Submitter:

Simone Forterre

Date Deposited:

22 Sep 2014 14:47

Last Modified:

22 Jan 2019 13:20

Publisher DOI:

10.1007/s00418-014-1218-x

PubMed ID:

24748503

Uncontrolled Keywords:

Dura, Pain, Modalities, Immunohistochemistry, Sympathetic innervation, Intervertebral disc herniation

BORIS DOI:

10.7892/boris.58772

URI:

https://boris.unibe.ch/id/eprint/58772

Actions (login required)

Edit item Edit item
Provide Feedback