Levels of retinol and retinyl esters in plasma and urine of dogs with urolithiasis

Raila, Jens; Forterre, Simone; Schweigert, F. J. (2003). Levels of retinol and retinyl esters in plasma and urine of dogs with urolithiasis. Journal of veterinary medicine. Series A - physiology, pathology, clinical medicine, 50(7), pp. 380-382. Blackwell 10.1046/j.1439-0442.2003.00552.x

[img] Text
j.1439-0442.2003.00552.x.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (63kB) | Request a copy

Vitamin A (VA) deficiency and Tamm-Horsfall glycoprotein (THP), a protein that binds retinol and retinyl esters in canine urine, might be involved in the pathogenesis of urolithiasis in dogs. In the present study, we assessed levels of retinol, retinyl esters, retinol-binding protein (RBP) and THP in plasma and urine of dogs with a history of urolithiasis (n = 25) compared with clinically healthy controls (n = 18). Plasma retinol concentrations were higher in dogs with uroliths of struvit (P < 0.01), calcium oxalate (P < 0.05), urate (P < 0.01) and cysteine, but there were no differences in the concentrations of plasma RBP and retinyl esters. Excretion of urinary retinol and retinyl esters were tentatively, but not significantly higher in the stone-forming groups, which was accompanied by increased levels of urinary RBP (P < 0.01) and lower excretions in THP (P < 0.01). The results show that VA deficiency may be excluded as a potential cause for canine urolithiasis. However, the occurrence of RBP and a concomitant reduction of THP in urine indicates a disturbed kidney function as cause or consequence of stone formation in dogs.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Surgery
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic

UniBE Contributor:

Forterre, Simone

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

0931-184X

Publisher:

Blackwell

Language:

English

Submitter:

Simone Forterre

Date Deposited:

26 Sep 2014 09:14

Last Modified:

14 Dec 2014 04:22

Publisher DOI:

10.1046/j.1439-0442.2003.00552.x

PubMed ID:

14633234

BORIS DOI:

10.7892/boris.58816

URI:

https://boris.unibe.ch/id/eprint/58816

Actions (login required)

Edit item Edit item
Provide Feedback