Van Hemelrijck, Mieke; Feller, Anita; Garmo, Hans; Valeri, Fabio; Korol, Dimitri; Dehler, Silvia; Rohrmann, Sabine (2014). Incidence of second malignancies for prostate cancer. PLoS ONE, 9(7), e102596. Public Library of Science 10.1371/journal.pone.0102596
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INTRODUCTION
There is a need to assess risk of second primary cancers in prostate cancer (PCa) patients, especially since PCa treatment may be associated with increased risk of second primary tumours.
METHODS
We calculated standardized incidence ratios (SIRs) for second primary tumours comparing men diagnosed with PCa between 1980 and 2010 in the Canton of Zurich, Switzerland (n = 20,559), and the general male population in the Canton.
RESULTS
A total of 1,718 men developed a second primary tumour after PCa diagnosis, with lung and colon cancer being the most common (15 and 13% respectively). The SIR for overall second primary cancer was 1.11 (95%CI: 1.06-1.17). Site-specific SIRs varied from 1.19 (1.05-1.34) to 2.89 (2.62-4.77) for lung and thyroid cancer, respectively. When stratified by treatment, the highest SIR was observed for thyroid cancer (3.57 (1.30-7.76)) when undergoing surgery, whereas liver cancer was common when treated with radiotherapy (3.21 (1.54-5.90)) and kidney bladder was most prevalent for those on hormonal treatment (3.15 (1.93-4.87)). Stratification by time since PCa diagnosis showed a lower risk of cancer for men with PCa compared to the general population for the first four years, but then a steep increase in risk was observed.
CONCLUSION
In the Canton of Zurich, there was an increased risk of second primary cancers among men with PCa compared to the general population. Increased diagnostic activity after PCa diagnosis may partly explain increased risks within the first years of diagnosis, but time-stratified analyses indicated that increased risks remained and even increased over time.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Feller, Anita Katja, Valeri, Fabio |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1932-6203 |
Publisher: |
Public Library of Science |
Language: |
English |
Submitter: |
Doris Kopp Heim |
Date Deposited: |
18 Sep 2014 16:58 |
Last Modified: |
02 Mar 2023 23:25 |
Publisher DOI: |
10.1371/journal.pone.0102596 |
PubMed ID: |
25047238 |
BORIS DOI: |
10.7892/boris.58825 |
URI: |
https://boris.unibe.ch/id/eprint/58825 |
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