The Biological Side of Water-Soluble Arene Ruthenium Assemblies

Therrien, Bruno; Furrer, Julien (2014). The Biological Side of Water-Soluble Arene Ruthenium Assemblies. Advances in chemistry, 2014, pp. 1-20. Hindawi 10.1155/2014/589686

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This review article covers the synthetic strategies, structural aspects, and host-guest properties of ruthenium metalla-assemblies, with a special focus on their use as drug delivery vectors. The two-dimensional metalla-rectangles show interesting host-guest possibilities but seem less appropriate for being used as drug carriers. On the other hand, metalla-prisms allow encapsulation and possible targeted release of bioactive molecules and consequently show some potential as drug delivery vectors. The reactivity of these metalla-prisms can be fine-tuned to allow a fine control of the guest’s release. The larger metalla-cubes can be used to stabilize the formation of G-quadruplex DNA and can be used to encapsulate and release photoactive molecules such as porphins. These metalla-assemblies demonstrate great prospective in photodynamic therapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Furrer, Julien

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

2356-6612

Publisher:

Hindawi

Language:

English

Submitter:

Julien Henri Lucien Furrer

Date Deposited:

03 Oct 2014 14:42

Last Modified:

26 Jun 2016 01:54

Publisher DOI:

10.1155/2014/589686

BORIS DOI:

10.7892/boris.58844

URI:

https://boris.unibe.ch/id/eprint/58844

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