Estimating the Reproduction Number of Ebola Virus (EBOV) During the 2014 Outbreak in West Africa

Althaus, Christian L (2014). Estimating the Reproduction Number of Ebola Virus (EBOV) During the 2014 Outbreak in West Africa. PLoS currents, 6(version 1) Public Library of Science 10.1371/currents.outbreaks.91afb5e0f279e7f29e7056095255b288

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The 2014 Ebola virus (EBOV) outbreak in West Africa is the largest outbreak of the genus Ebolavirus to date. To better understand the spread of infection in the affected countries, it is crucial to know the number of secondary cases generated by an infected index case in the absence and presence of control measures, i.e., the basic and effective reproduction number. In this study, I describe the EBOV epidemic using an SEIR (susceptible-exposed-infectious-recovered) model and fit the model to the most recent reported data of infected cases and deaths in Guinea, Sierra Leone and Liberia. The maximum likelihood estimates of the basic reproduction number are 1.51 (95% confidence interval [CI]: 1.50-1.52) for Guinea, 2.53 (95% CI: 2.41-2.67) for Sierra Leone and 1.59 (95% CI: 1.57-1.60) for Liberia. The model indicates that in Guinea and Sierra Leone the effective reproduction number might have dropped to around unity by the end of May and July 2014, respectively. In Liberia, however, the model estimates no decline in the effective reproduction number by end-August 2014. This suggests that control efforts in Liberia need to be improved substantially in order to stop the current outbreak.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Althaus, Christian

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

2157-3999

Publisher:

Public Library of Science

Language:

English

Submitter:

Beatrice Minder Wyssmann

Date Deposited:

14 Oct 2014 07:55

Last Modified:

10 Sep 2017 09:46

Publisher DOI:

10.1371/currents.outbreaks.91afb5e0f279e7f29e7056095255b288

PubMed ID:

25642364

BORIS DOI:

10.7892/boris.58891

URI:

https://boris.unibe.ch/id/eprint/58891

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