Vyborna, Yuliia; Vybornyi, Mykhailo; Häner, Robert (29 August 2014). Hierarchical self-assembly of nucleotide-appended oligopyrenotides into defined supramolecular objects. In: 7th International Conference On Molecular Electronics. Strasbourg, France. August 24th – August 29th, 2013.
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Supramolecular DNA assembly blends DNA building blocks with synthetic organic and inorganic molecules giving structural and functional advantages both to the initial self-assembly process and to the final construct.
Synthetic molecules can bring a number of additional interactions into DNA nanotechnology. Incorporating extended aromatic molecules as connectors of DNA strands allows folding of these strands through π-π stacking (DNA “foldamers”).
In previous work it was shown that short oligopyrenotides (phosphodiester-linked pyrene oligomers) behave as staircase-like foldamers, which cooperatively self-assemble into two-dimensional supramolecular polymers in aqueous medium.
Herein, we demonstrate that a 10-mer DNA-sequence modified with 7 pyrene units (see illustration) forms dimensionally-defined supramolecular polymers under thermodynamic conditions in water. We present the self-assembly behavior, morphological studies, and the spectroscopic properties of the investigated DNA-sequences (illustrative AFM picture shown below).
Item Type: |
Conference or Workshop Item (Poster) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Vyborna, Yuliia, Vybornyi, Mykhailo, Häner, Robert |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
Language: |
English |
Submitter: |
Yuliia Vyborna |
Date Deposited: |
02 Oct 2014 14:24 |
Last Modified: |
05 Dec 2022 14:37 |
BORIS DOI: |
10.7892/boris.58920 |
URI: |
https://boris.unibe.ch/id/eprint/58920 |
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