Hierarchical self-assembly of nucleotide-appended oligopyrenotides into defined supramolecular objects

Vyborna, Yuliia; Vybornyi, Mykhailo; Häner, Robert (29 August 2014). Hierarchical self-assembly of nucleotide-appended oligopyrenotides into defined supramolecular objects. In: 7th International Conference On Molecular Electronics. Strasbourg, France. August 24th – August 29th, 2013.

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Supramolecular DNA assembly blends DNA building blocks with synthetic organic and inorganic molecules giving structural and functional advantages both to the initial self-assembly process and to the final construct. Synthetic molecules can bring a number of additional interactions into DNA nanotechnology. Incorporating extended aromatic molecules as connectors of DNA strands allows folding of these strands through π-π stacking (DNA “foldamers”). In previous work it was shown that short oligopyrenotides (phosphodiester-linked pyrene oligomers) behave as staircase-like foldamers, which cooperatively self-assemble into two-dimensional supramolecular polymers in aqueous medium. Herein, we demonstrate that a 10-mer DNA-sequence modified with 7 pyrene units (see illustration) forms dimensionally-defined supramolecular polymers under thermodynamic conditions in water. We present the self-assembly behavior, morphological studies, and the spectroscopic properties of the investigated DNA-sequences (illustrative AFM picture shown below).

Item Type:

Conference or Workshop Item (Poster)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Vyborna, Yuliia; Vybornyi, Mykhailo and Häner, Robert

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

Language:

English

Submitter:

Yuliia Vyborna

Date Deposited:

02 Oct 2014 14:24

Last Modified:

26 Apr 2017 02:29

BORIS DOI:

10.7892/boris.58920

URI:

https://boris.unibe.ch/id/eprint/58920

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