Hierarchical self-assembly of nucleotide-appended oligopyrenotides into defined supramolecular objects

Vyborna, Yuliia; Vybornyi, Mykhailo; Häner, Robert (29 August 2014). Hierarchical self-assembly of nucleotide-appended oligopyrenotides into defined supramolecular objects. In: 7th International Conference On Molecular Electronics. Strasbourg, France. August 24th – August 29th, 2013.

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Supramolecular DNA assembly blends DNA building blocks with synthetic organic and inorganic molecules giving structural and functional advantages both to the initial self-assembly process and to the final construct.
Synthetic molecules can bring a number of additional interactions into DNA nanotechnology. Incorporating extended aromatic molecules as connectors of DNA strands allows folding of these strands through π-π stacking (DNA “foldamers”).
In previous work it was shown that short oligopyrenotides (phosphodiester-linked pyrene oligomers) behave as staircase-like foldamers, which cooperatively self-assemble into two-dimensional supramolecular polymers in aqueous medium.
Herein, we demonstrate that a 10-mer DNA-sequence modified with 7 pyrene units (see illustration) forms dimensionally-defined supramolecular polymers under thermodynamic conditions in water. We present the self-assembly behavior, morphological studies, and the spectroscopic properties of the investigated DNA-sequences (illustrative AFM picture shown below).

Item Type:

Conference or Workshop Item (Poster)


08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

UniBE Contributor:

Vyborna, Yuliia, Vybornyi, Mykhailo, Häner, Robert


500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry




Yuliia Vyborna

Date Deposited:

02 Oct 2014 14:24

Last Modified:

05 Dec 2022 14:37





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