Hierarchical self-assembly of nucleotide-appended oligopyrenotides into defined supramolecular objects

Vyborna, Yuliia; Vybornyi, Mykhailo; Häner, Robert (11 August 2014). Hierarchical self-assembly of nucleotide-appended oligopyrenotides into defined supramolecular objects. CHIMIA, 68(7-8, Suppl). Bern: Schweizerische Chemische Gesellschaft

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Supramolecular DNA assembly blends DNA building blocks with synthetic
organic molecules giving structural and functional advantages. Incorporating
extended aromatic molecules as connectors of DNA strands allows folding of
these strands through π-π stacking (DNA 'foldamers'). In previous work it was
shown that short oligopyrenotides behave as staircase-like foldamers, which
cooperatively self-assemble into 2D supramolecular polymers in aqueous
medium. Herein, we demonstrate that 10-mer DNA-sequence conjugated with
seven pyrene unites forms dimensionally-defined supramolecular polymers under
thermodynamic conditions in water. We present the self-assembly behavior,
morphologycal studies (AFM and TEM), and the spectroscopic properties
(UV/vis, CD) of the investigated pyrene - conjugated DNA-sequence.

Item Type:

Conference or Workshop Item (Poster)

Division/Institute:

08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

UniBE Contributor:

Vyborna, Yuliia; Vybornyi, Mykhailo and Häner, Robert

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0009-4293

Publisher:

Schweizerische Chemische Gesellschaft

Language:

English

Submitter:

Yuliia Vyborna

Date Deposited:

06 Oct 2014 11:19

Last Modified:

26 Apr 2017 02:29

BORIS DOI:

10.7892/boris.58925

URI:

https://boris.unibe.ch/id/eprint/58925

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