Validation of a magnetic resonance imaging guided stereotactic access to the ovine brainstem.

Staudacher, Anne; Oevermann, Anna; Stoffel, Michael Hubert; Gorgas, Daniela (2014). Validation of a magnetic resonance imaging guided stereotactic access to the ovine brainstem. BMC veterinary research, 10(216), p. 216. BioMed Central 10.1186/s12917-014-0216-5

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BackgroundAnatomical differences between humans and domestic mammals preclude the use of reported stereotactic approaches to the brainstem in animals. In animals, brainstem biopsies are required both for histopathological diagnosis of neurological disorders and for research purposes. Sheep are used as a translational model for various types of brain disease and therefore a species-specific approach needs to be developed. The aim of the present study was to establish a minimally invasive, accurate and reproducible stereotactic approach to the brainstem of sheep, using the magnetic resonance imaging guided BrainsightTM frameless stereotactic system.ResultsA transoccipital transcerebellar approach with an entry point in the occipital bone above the vermis between the transverse sinus and the external occipital protuberance was chosen. This approach provided access to the target site in all heads. The overall mean needle placement error was 1.85¿±¿1.22 mm.ConclusionsThe developed transoccipital transcerebellar route is short, provides accurate access to the ovine caudal cranial fossa and is a promising approach to be assessed further in live animals.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Radiology
05 Veterinary Medicine > Research Foci > NeuroCenter
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Anatomy
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Staudacher, Anne; Oevermann, Anna; Stoffel, Michael Hubert and Schweizer, Daniela Esther

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

1746-6148

Publisher:

BioMed Central

Language:

English

Submitter:

Michael Hubert Stoffel

Date Deposited:

15 Oct 2014 16:01

Last Modified:

01 Nov 2017 10:49

Publisher DOI:

10.1186/s12917-014-0216-5

PubMed ID:

25241810

BORIS DOI:

10.7892/boris.58944

URI:

https://boris.unibe.ch/id/eprint/58944

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