The ovine cerebral venous system: comparative anatomy, visualization, and implications for translational research.

Hoffmann, Anke; Stoffel, Michael Hubert; Nitzsche, Björn; Lobsien, Donald; Seeger, Johannes; Schneider, Holm; Boltze, Johannes (2014). The ovine cerebral venous system: comparative anatomy, visualization, and implications for translational research. PLoS ONE, 9(4), e92990. Public Library of Science 10.1371/journal.pone.0092990

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Cerebrovascular diseases are significant causes of death and disability in humans. Improvements in diagnostic and therapeutic approaches strongly rely on adequate gyrencephalic, large animal models being demanded for translational research. Ovine stroke models may represent a promising approach but are currently limited by insufficient knowledge regarding the venous system of the cerebral angioarchitecture. The present study was intended to provide a comprehensive anatomical analysis of the intracranial venous system in sheep as a reliable basis for the interpretation of experimental results in such ovine models. We used corrosion casts as well as contrast-enhanced magnetic resonance venography to scrutinize blood drainage from the brain. This combined approach yielded detailed and, to some extent, novel findings. In particular, we provide evidence for chordae Willisii and lateral venous lacunae, and report on connections between the dorsal and ventral sinuses in this species. For the first time, we also describe venous confluences in the deep cerebral venous system and an 'anterior condylar confluent' as seen in humans. This report provides a detailed reference for the interpretation of venous diagnostic imaging findings in sheep, including an assessment of structure detectability by in vivo (imaging) versus ex vivo (corrosion cast) visualization methods. Moreover, it features a comprehensive interspecies-comparison of the venous cerebral angioarchitecture in man, rodents, canines and sheep as a relevant large animal model species, and describes possible implications for translational cerebrovascular research.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Anatomy

UniBE Contributor:

Stoffel, Michael Hubert

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Michael Hubert Stoffel

Date Deposited:

15 Oct 2014 08:13

Last Modified:

05 Feb 2015 10:21

Publisher DOI:

10.1371/journal.pone.0092990

PubMed ID:

24736654

BORIS DOI:

10.7892/boris.58961

URI:

https://boris.unibe.ch/id/eprint/58961

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