Adhesive Strength of a β-Tricalcium Phosphate-Enriched Bone Adhesive

Kraus, R; Peters, F; Geck, A; Lips, KS; Obert, M; Röder, C; Schnabelrauch, M; Schnettler, R; Heiss, C.Z (2011). Adhesive Strength of a β-Tricalcium Phosphate-Enriched Bone Adhesive. Zeitschrift für Orthopädie und Unfallchirurgie, 149(3), pp. 271-278. Stuttgart: Thieme 10.1055/s-0030-1270709

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Background: This investigation describes experimental tests of the biomechanical features of a new resorbable bone adhesive based on methacrylate-terminated oligolactides enhanced with osteoconductive β-tricalcium phosphate. Material and Methods: 51 New Zealand white rabbits were randomised to an adhesive group (n = 29) and a control group (n = 22). An extra-articular bone cylinder was taken from the proximal tibia, two stripes of adhesive were applied and the cylinders were replanted. After 10 and 21 days, 3 and 12 months tibial specimens were harvested and the cylinder pull-out test was performed with a servo-hydraulic machine. Additionally the pull-out force was evaluated with the bone-equivalent Ebazell® after 5, 10 and 360 minutes in 14 specimens each. Results: Average pull-out forces in the adhesive group were 28 N after 10 days (control: 57 N), 155 N after 21 days (216 N), 184 N after 3 months (197 N) and 205 N after 12 months (185 N). Investigations with Ebazell® showed almost identical pull-out forces after 5 min, 15 min and 360 min. Adhesive forces were as high as 125 N/cm2 of adhesive surface and more than 1200 N/g of adhesive mass. Conclusions: The adhesive investigated here has a very good primary adhesive power, compared to the literature data, achieved after only 5 minutes. Even in moist surroundings the adhesive capacity remains sufficient. The adhesive has to prove its resorptive properties in further investigations and in first line its medium-term and long-lasting biocompatibility. Furthermore, biomechanical features will have to be compared to those of conventional fixation techniques.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Evaluative Research into Orthopaedic Surgery

UniBE Contributor:

Röder, Christoph

ISSN:

1864-6697

Publisher:

Thieme

Language:

German

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:19

Last Modified:

07 Apr 2014 22:11

Publisher DOI:

10.1055/s-0030-1270709

PubMed ID:

21567362

Web of Science ID:

000291726700003

URI:

https://boris.unibe.ch/id/eprint/5907 (FactScience: 210784)

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