Long-Term Comparison of Everolimus-Eluting and Biolimus-Eluting Stents in All-Comer Patients

Puricel, Serban-George; Oberhänsli, Markus; Guntern, Patricia; Lehmann, Sonja; Goy, Jean-Jacques; Arroyo, Diego Andoni; Villeneuve, Hélène; Baeriswyl, Gérard; Stauffer, Jean-Christophe; Togni, Mario; Cook, Stéphane (2013). Long-Term Comparison of Everolimus-Eluting and Biolimus-Eluting Stents in All-Comer Patients. EuroIntervention, 8, pp. 336-344. Europa Digital & Publishing

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AIMS: Second-generation everolimus-eluting stents (EES) are safer and more efficient than first-generation paclitaxel-eluting stents (PES). Third-generation biolimus-eluting stents (BES) have been found to be non-inferior to PES. To date, there is no available comparative study between EES and BES. We aimed to investigate the safety and efficacy of BES with biodegradable polymer compared to EES with durable polymer at a follow-up of two years in an unselected population of consecutively enrolled patients. METHODS AND RESULTS: A group of 814 consecutive patients undergoing percutaneous coronary intervention (PCI) was enrolled between 2007 and 2010, of which 527 were treated with EES and 287 with BES implantation. Clinical outcome was compared in 200 pairs using propensity score matching. The primary endpoint was a composite of death, myocardial infarction (MI) and target vessel revascularisation (TVR) at two-year follow-up. Median follow-up was 22 months. The primary outcome occurred in 11.5% of EES and 10.5% of BES patients (HR 1.11, 95% CI: 0.61-2.00, p=0.74). At two years, there was no significant difference with regard to death (HR 0.49, 95% CI: 0.18-1.34, p=0.17), cardiac death (HR 0.14, 95% CI: 0.02-1.14, p=0.66) or MI (HR 6.10, 95% CI: 0.73-50.9, p=0.10). Stent thrombosis (ST) incidence was evenly distributed between EES (n=2) and BES (n=2) (p-value=1.0). CONCLUSIONS: This first clinical study failed to demonstrate any significant difference regarding safety or efficacy between these two types and generations of drug-eluting stents (DES).

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Other Institutions > Teaching Staff, Faculty of Medicine
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UniBE Contributor:

Puricel, Serban-George; Oberhänsli, Markus; Arroyo, Diego Andoni; Togni, Mario and Cook, Stéphane


600 Technology > 610 Medicine & health




Europa Digital & Publishing




Diego Andoni Arroyo

Date Deposited:

09 Oct 2014 10:49

Last Modified:

10 Sep 2017 13:52





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