Ten year clinical follow-up after Sirolimus-eluting stent implantation

Palhais, Nuno; Arroyo, Diego Andoni; Lehmann, Sonja; Togni, Mario; Kaufmann, Urs; Stauffer, Jean-Christophe; Goy, Jean-Jacques; Cook, Stéphane (2014). Ten year clinical follow-up after Sirolimus-eluting stent implantation. American Heart Journal, 167(6), pp. 893-899. Elsevier 10.1016/j.ahj.2013.12.013

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BACKGROUND: Little is known on the "very" long-term incidence of major adverse cardiac events (MACE), target-lesion revascularization (TLR), target-vessel revascularization and stent thrombosis after sirolimus-eluting stent (SES) implantation. We present the first study to provide a 10-year clinical follow-up in an unselected patient population who underwent SES implantation. METHODS AND RESULTS: We ran a systematic 10-year clinical follow-up in a series of 200 consecutive patients treated with unrestricted SES implantation between April 2002 and April 2003 in two Swiss hospitals. Outcomes and follow-up were obtained in all 200 patients. The cumulative 10-year MACE rate was 47% with all-cause death of 20%, cardiac death of 9%, myocardial infarction of 7%, TLR and target-vessel revascularization of 8% and 11% respectively. Academic Research Consortium-defined "definite and probable" stent thrombosis-rate was 2.5%. TLR risk was maximal between 3 to 6 years. New lesion revascularization increased throughout the study period. CONCLUSION: Incidence of TLR was maximal 3 to 6 years after SES implantation and decreased thereafter. MACE and non-TLR revascularization rates steadily increased during the complete follow-up underlining the progression of coronary artery disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Arroyo, Diego Andoni

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0002-8703

Publisher:

Elsevier

Language:

English

Submitter:

Diego Andoni Arroyo

Date Deposited:

13 Oct 2014 15:37

Last Modified:

29 Oct 2015 11:10

Publisher DOI:

10.1016/j.ahj.2013.12.013

BORIS DOI:

10.7892/boris.59142

URI:

https://boris.unibe.ch/id/eprint/59142

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