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[ ( ) 215 (\251 2014 S\056 Karger AG\054 Basel ) ] TJ
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[ ( ) 215 (Received\072 April 7\054 2013 ) ] TJ
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[ ( ) 209.8 (Accepted after revision\072 July 6\054 2013 ) ] TJ
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[ ( ) 215 (Published online\072 January 9\054 2014 ) ] TJ
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[ ( E\055Mail ) -227 (Thekla\056Renker ) ] TJ
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0 Tw
<04> Tj
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-0.227 Tw
[ ( \100 ) ] TJ
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0 Tw
<04> Tj
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-0.227 Tw
[ ( insel\056ch ) ] TJ
-34.7307 4.5714 TD
0 Tw
[ ( ) 227 (\251 2014 S\056 Karger AG\054 Basel) ] TJ
0 -1.1429 TD
(1018\2058665\05714\0572282\2050097\04439\05650\0570 ) Tj
ET
0.5 w
4 M
/GS2 gs
42.52 676.928 m
S
/GS3 gs
BT
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-0.227 Tw
[ ( www\056karger\056com\057drm ) ] TJ
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-0.0215 Tw
(light\055chain proteins found in diseases such ) Tj
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0.1381 Tw
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T*
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(macroglobulinemia ) Tj
ET
/GS2 gs
BT
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/Cs8 cs
1 scn
0 Tw
(\1332\135) Tj
ET
/GS3 gs
BT
9.5 0 0 9.5 479.774 415.057 Tm
/Cs6 cs
0.13725 0.12157 0.12549 scn
0.0777 Tw
[ ( ) 304.7 (\056 Amyloid proteins ) ] TJ
-9.3256 -1.1169 TD
0.248 Tw
(can accumulate in virtually every organ ) Tj
T*
0.149 Tw
(with the exception of parenchymal brain ) Tj
T*
0.1243 Tw
(tissue\056 Cutaneous manifestations\054 such as ) Tj
T*
0.2708 Tw
(purpura\054 petechiae and ecchymoses\054 are ) Tj
T*
-0.0205 Tw
(observed in about 50\045 of cases of AL amy\055) Tj
T*
0.0536 Tw
(loidosis and provide important diagnostic ) Tj
T*
0 Tw
(clues\056) Tj
1.3427 -1.1169 TD
0.1259 Tw
[ ( ) 352.9 ( ) 352.9 (We here report a striking case of sys\055) ] TJ
-1.3427 -1.1169 TD
0.1555 Tw
(temic amyloidosis of the AL type\054 which ) Tj
T*
-0.0113 Tw
(was revealed by the insidious development ) Tj
T*
0.0567 Tw
(over years of nail changes in combination ) Tj
T*
0.3495 Tw
(with parchment\055like hand involvement\054 ) Tj
T*
0.4098 Tw
(diffuse generalized hair loss and sicca ) Tj
T*
0.253 Tw
(symptoms which were first related to a ) Tj
T*
0 Tw
(connective tissue disease\056) Tj
/F271cb29b8-26d1-42df-8337-7319dde3a071 1 Tf
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-0.202 Tc
[ ( C) -211.8 (a) -214.5 (s) -215.1 (e) -205 ( ) -205 (R) -214.2 (e) -220.3 (p) -219 (o) -215.7 (r) -231.1 (t) -202 ( ) ] TJ
/F1f1c9f118-98ff-4859-8bb6-a5ef34a814b2 1 Tf
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0 Tc
0.2001 Tw
[ ( ) 427.1 (A 66\055year\055old Caucasian woman was ) ] TJ
-1.3427 -1.117 TD
0.0038 Tw
(referred by the treating rheumatologist for ) Tj
T*
0.1044 Tw
(evaluation of a 15\055year history of asymp\055) Tj
0 -1.1168 TD
0.0912 Tw
(tomatic skin changes involving the hands ) Tj
0 -1.117 TD
0.0368 Tw
(associated with nail changes and hair loss\054 ) Tj
0 -1.1171 TD
0.1157 Tw
(which were thought to be secondary to a ) Tj
0 -1.1168 TD
-0.0047 Tw
(connective tissue disease\056 During the last 5 ) Tj
0 -1.117 TD
-0.0644 Tw
(years\054 she had also been suffering from dry\055) Tj
T*
-0.0591 Tw
(ness of the mouth and eyes\054 which was con\055) Tj
T*
0.0002 Tw
(firmed by Saxon\220s and Schirmer\220s tests\054 re\055) Tj
T*
0.235 Tw
(spectively\056 Furthermore\054 she reported to ) Tj
ET
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