Galichet, Arnaud; Borradori, Luca; Müller, Eliane Jasmine (2014). A new light on an old disease: adhesion signaling in pemphigus vulgaris. Journal of Investigative Dermatology, 134(1), pp. 8-10. Nature Publishing 10.1038/jid.2013.439
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Disruption of desmosomal cadherin adhesion leads to the activation of intracellular signaling pathways that are responsible for blister formation in pemphigus vulgaris (PV). Recent studies corroborate the implication of the p38 mitogen-activated protein kinase in PV blistering via its downstream effector mitogen-activated protein kinase activated protein kinase 2. These insights highlight the key role of cadherins in tissue homeostasis and are expected to change pemphigus management.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology 04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology 05 Veterinary Medicine > Research Foci > DermFocus 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) |
UniBE Contributor: |
Galichet, Arnaud, Borradori, Luca, Müller, Eliane Jasmine |
Subjects: |
600 Technology > 610 Medicine & health 600 Technology > 630 Agriculture |
ISSN: |
0022-202X |
Publisher: |
Nature Publishing |
Language: |
English |
Submitter: |
Monika Schenk |
Date Deposited: |
09 Apr 2015 11:48 |
Last Modified: |
05 Dec 2022 14:37 |
Publisher DOI: |
10.1038/jid.2013.439 |
PubMed ID: |
24352077 |
BORIS DOI: |
10.7892/boris.59186 |
URI: |
https://boris.unibe.ch/id/eprint/59186 |
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